Transcription Factor
| Accessions: | DRGX_DBD (HumanTF 1.0), DRGX_TF2 (HumanTF2 1.0), DRGX (HT-SELEX2 May2017) |
| Names: | Dorsal root ganglia homeobox protein, DRGX, DRGX_HUMAN, Paired-related homeobox protein-like 1, ENSG00000165606 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | A6NNA5 |
| Notes: | Ensembl ID: ENSG00000165606; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000165606; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 114 |
| Pfam Domains: | 32-88 Homeobox domain |
| Sequence: (in bold interface residues) | 1 YFHCPPQLEGTATFGNHSSGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFT 60 61 REELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRN |
| Interface Residues: | 31, 32, 33, 34, 35, 73, 74, 76, 77, 80, 81, 84, 85, 88 |
| 3D-footprint Homologues: | 4j19_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 2lkx_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2ld5_A, 2hdd_A, 7q3o_C, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1o4x_A, 8g87_X, 1du0_A, 5zjt_E |
| Binding Motifs: | DRGX_DBD hTAATytAATTAa E2F3_DRGX sGCGCTAATTks ETV2_DRGX_1 rsCGGAWryaATTA ETV2_DRGX_2 rcCGGAwryatTa ETV5_DRGX_1 rsmGGAAGyAATTA ETV5_DRGX_2 TaAtkrsCGGAwGy FLI1_DRGX aCCGGAwGyAATTAt GCM2_DRGX_1 rTrsGGGtaATTag GCM2_DRGX_2 ATrcGGGytaaTtak MEIS1_DRGX_1 tGACrstaATtr MEIS1_DRGX_2 TGTCAATTA- TEAD4_DRGX_1 gghATGyTAATTr TEAD4_DRGX_2 GGwATGTTAATtr TFAP2C_DRGX sCCysrGGsrayaATTA DRGX_2 yyAATTAs DRGX_methyl_1 yyAATTAs |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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