Transcription Factor
| Accessions: | P41161 (JASPAR 2024) |
| Names: | ETS translocation variant 5, Ets-related protein ERM, ETV5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 510 |
| Pfam Domains: | 1-366 PEA3 subfamily ETS-domain transcription factor N terminal domain 368-449 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAE 60 61 AQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNY 120 121 CAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHS 180 181 LPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNR 240 241 PSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYC 300 301 VDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGP 360 361 PYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYD 420 421 KLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDT 480 481 LPLTHFEDSPAYLLDMDRCSSLPYAEGFAY |
| Interface Residues: | 420, 421, 424, 425, 427, 428, 442 |
| 3D-footprint Homologues: | 8ee9_F, 8smh_F, 8smj_F, 7jsa_J, 1yo5_C |
| Binding Motifs: | MA0765.1 acCGGAwgyr MA1944.1 rsmGGAAGyAATTA MA1948.1 rsCGGAwGTmATTA MA0765.2 bcACTTCCGsy MA0765.3 ACCGGAAGTr MA0765.4 ACCGGAAGT MA1944.2 mGGAAGyAATTA MA1948.2 CGGAwGTmATTA |
| Binding Sites: | MA0765.2.1 MA0765.2.10 MA0765.2.11 MA0765.2.12 MA0765.2.13 MA0765.2.14 MA0765.2.15 MA0765.2.16 MA0765.2.17 MA0765.2.18 MA0765.2.19 MA0765.2.2 MA0765.2.20 / MA0765.2.9 MA0765.2.3 MA0765.2.4 MA0765.2.5 MA0765.2.6 MA0765.2.7 MA0765.2.8 |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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