DNA Binding Motif

						

			
Accessions: HOXB2_TBX21_1 (HumanTF2 1.0), UN0564.1 (JASPAR 2024)

			
Names: HOXB2_TBX21, HOXB2::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 13
Consensus: ragGTGyTAATkr
Weblogo: 
PSSM: P0      A      C      G      T
01    970    410   1447    918      r
02   3744    244   1244    484      a
03    733    773   3744    676      g
04     74    255   3744    112      G
05    100    509     70   3744      T
06     47     37   3744     21      G
07    453    948    215   2128      y
08    973    138    294   3744      T
09   3744     14    915     68      A
10   3744     18     38      9      A
11     94    407    276   3744      T
12    268    359   2275   1469      k
13   1542    501   2201    934      r
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
TBX21_TF2 (T-box)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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