DNA Binding Motif

						

			
Accessions: ETV5_FIGLA (HumanTF2 1.0), MA1945.1 (JASPAR 2024)

			
Names: ETV5_FIGLA, ETV5::FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: rgmGGAArCAGGTGg
Weblogo: 
PSSM: P0      A      C      G      T
01    797    214   1043    228      r
02    405    577   1262    161      g
03    774   1839    401     72      m
04     12      4   1839      5      G
05      0      3   1839     98      G
06   1839     41     25     24      A
07   1839     47     56    598      A
08    700    177   1139     35      r
09      7   1839     20     24      C
10   1839     10     26      3      A
11     15    377   1839     10      G
12     64    477   1839      5      G
13     18     12     40   1839      T
14     15     12   1839     34      G
15    236    296    930    378      g
Type: Heterodimer
Binding TFs: ETV5_TF1 (Ets-domain)
FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Q6QHK4
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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