DNA Binding Motif

						

			
Accessions: ERF_FIGLA (HumanTF2 1.0), MA1934.1 (JASPAR 2024)

			
Names: ERF_FIGLA, ERF::FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rcCGGAwrCAssTGky
Weblogo: 
PSSM: P0      A      C      G      T
01   8107   1852   4162   2329      r
02   1887   9034   3235    394      c
03   4153  12269    297     62      C
04     13     29  12269     13      G
05     33      3  12269     58      G
06  12269     44     24     19      A
07  12269    456     62   5547      w
08   5798   2446   3829    196      r
09     46  12269      0     15      C
10  12269     44     50      9      A
11     25   7225   5044    126      s
12    292  12269   6088     83      s
13     22    436    189  12269      T
14     31     31  12269    205      G
15   1748   2654   4055   3812      k
16   2810   3307   2723   3428      y
Type: Heterodimer
Binding TFs: FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
ERF_TF1 (Ets-domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Q6QHK4
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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