Transcription Factor

						

			
Accessions: 4zpk_B (3D-footprint 20231221)

			
Names: Endothelial PAS domain-containing protein 1, EPAS-1, EPAS1_MOUSE, HIF-1-alpha-like factor, HIF-2-alpha, HIF-related factor, HIF2-alpha, HLF, HRF, Hypoxia-inducible factor 2-alpha, mHLF
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P97481
Length: 321
Pfam Domains:    86-155 PAS fold
  215-300 PAS domain
  218-295 PAS fold
  220-302 PAS fold
Sequence: 
(in bold interface residues)		   1 KRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTH   60
  61 KLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELT  120
 121 GHSIFDFTHPCDHEEIRENLTLSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVR  180
 181 VYNLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGR  240
 241 SAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNLQPQCIM  300
 301 CVNYVLSEIKNDVVFSMDQTE
Interface Residues: 8, 9, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
3D-footprint Homologues: 4zpr_B, 1a0a_B, 7xhv_B, 4zpk_A, 5nj8_D, 7xi3_A, 4zpk_B, 5sy7_B, 7xi3_B, 5v0l_A, 4h10_B, 8osl_O, 5nj8_C, 4h10_A
Binding Motifs: 4zpk_AB ACGTGCG
Binding Sites: 4zpk_C
4zpk_D
			
Publications: Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature 524:303-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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