DNA Binding Site

Accessions: 4zpk_C (3D-footprint 20231221), 5sy7_C (3D-footprint 20231221)
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 18
Sequence: CTGCGTACGTGCGGGTCG
Type: Heterodimer
Binding TFs: 4zpk_A (Helix-loop-helix DNA-binding domain, PAS fold, PAS fold, PAS domain)
4zpk_B (PAS fold, PAS fold, PAS domain)
5sy7_B (PAS fold, PAS fold)
Binding Motifs: 4zpk_A CGCACG
4zpk_AB ACGTGCG
5sy7_AB aCGTGCg
Publications: Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature 524:303-8 (2015). [Pubmed]

Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife : (2016). [Pubmed]

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