Transcription Factor

Accessions: 5yi3_I (3D-footprint 20231221)
Names: Q9CDU5_LACLA, Zinc transport transcriptional regulator
Organisms: Lactococcus lactis, Lactococcus lactis subsp. lactis (strain IL1403)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 145
Pfam Domains: 35-90 MarR family
35-92 MarR family
36-81 Winged helix-turn-helix DNA-binding
36-99 Winged helix DNA-binding domain
41-82 Bacterial regulatory protein, arsR family
41-84 Transcriptional regulator
42-81 Iron dependent repressor, N-terminal DNA binding domain
42-114 TFIIE alpha subunit
Sequence:
(in bold interface residues)
1 MSLANQIDQFLGTIMQFAENKHEILLGKSESDVKLTSTQEHILMLLAEQISTNAKIAEKL 60
61 KISPAAVTKALKKLQEQELIKSSRATNDERVVLWSLTEKAVPVAKEHATHHEKTLSTYQE 120
121 LGNKFTDEEQEVISKFLSALTEEFQ
Interface Residues: 36, 38, 53, 63, 64, 65, 66, 68, 69, 70, 73, 90
3D-footprint Homologues: 4kdp_B, 7el3_B, 5yi2_J, 6c2s_C, 1z9c_A, 6jbx_A, 3q5f_A, 3zpl_B, 8c7s_A, 4aik_A, 5hlg_E
Binding Motifs: 5yi3_I TTAACT
Binding Sites: 5yi3_K / 5yi3_L
Publications: Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc Natl Acad Sci U S A 114:13661-13666 (2017). [Pubmed]
Related annotations: PaperBLAST

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