Transcription Factor

Accessions: 3zql_B (3D-footprint 20231221), 3zql_D (3D-footprint 20231221)
Names: PUTATIVE REPRESSOR SIMREG2, Q9AMH9_STRAT, Sim16
Organisms: Streptomyces antibioticus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9AMH9
Length: 226
Pfam Domains: 16-60 Bacterial regulatory proteins, tetR family
73-223 Tetracyclin repressor, C-terminal all-alpha domain
Sequence:
(in bold interface residues)
1 VSIWMHPEPTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVE 60
61 LMVDEVIGETRLPDRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVWGPNSLRQQ 120
121 EFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVDMREWMRRSGPYA 180
181 QQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLD
Interface Residues: 34, 35, 44, 45, 46, 47, 49, 50, 154
3D-footprint Homologues: 5gpc_B, 6gy3_A, 5haw_A, 5yej_B, 3zql_B, 5fmp_B, 4gck_A, 1qpi_A, 4pxi_B, 2yvh_A, 7amn_A, 6en8_C, 7jnp_A, 6wpa_A, 5cl8_A
Binding Motifs: 3zql_AB TCGTACGnCGTACAA
3zql_B TTCGTACG
3zql_CD TTGTACGnCGTAcGA
Binding Sites: 3zql_E / 3zql_G
3zql_F / 3zql_H
Publications: Le T.B, Schumacher M.A, Lawson D.M, Brennan R.G, Buttner M.J. The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding. Nucleic acids research 39:9433-47 (2011). [Pubmed]
Related annotations: PaperBLAST

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