Transcription Factor
| Accessions: | 3d71_A (3D-footprint 20231221) |
| Names: | BMRR_BACSU, Multidrug-efflux transporter 1 regulator |
| Organisms: | Bacillus subtilis, strain 168 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P39075 |
| Length: | 277 |
| Pfam Domains: | 5-72 MerR HTH family regulatory protein 6-44 MerR family regulatory protein 123-275 GyrI-like small molecule binding domain |
| Sequence: (in bold interface residues) | 1 KESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRYYTDSQLIHLDLIKSLKY 60 61 IGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALEQTISLVKKRMKRQMEYPAL 120 121 GEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIESADGFTNNSYGATFSFQPYTS 180 181 IDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYACIAYNFSPEHYFLNLQKLIKYIA 240 241 DRQLTVVSDVYQLIIPIHYSPKKQEEYRVEMKIRILD |
| Interface Residues: | 19, 22, 23, 26, 39, 41, 42 |
| 3D-footprint Homologues: | 6ldi_G, 1r8d_B, 7tea_B, 4r24_B, 6xh7_H, 1r8e_A, 5d8c_A, 6xl5_H, 2vz4_A, 6jgx_B, 7ckq_G, 2zhg_A |
| Binding Motifs: | 3d71_A CCCT |
| Binding Sites: | 3d71_M |
| Publications: | Newberry K.J, Huffman J.L, Miller M.C, Vazquez-Laslop N, Neyfakh A.A, Brennan R.G. Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. The Journal of biological chemistry 283:26795-804 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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