Transcription Factor

						

			
Accessions: 3brd_A (3D-footprint 20231221)

			
Names: Lin-12 and glp-1 phenotype protein 1, isoform a, Q8MXE7_CAEEL
Organisms: Caenorhabditis elegans
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q8MXE7
Length: 427
Pfam Domains:    23-152 LAG1, DNA binding
  154-302 Beta-trefoil DNA-binding domain
  343-424 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQGWKLKKD   60
  61 RVAQLYKTLQQATELVAYIGIGSDTSERQQLDFPNIYDYCAAKTLYISDSDKRKYFDLNA  120
 121 QFFYGCGMEIGGFVSQRIKVISKPSKKKTDCKYLCIASGTKVALFNRLRSQTVSTRYLHV  180
 181 EGNAFHASSTKWGAFTIHLFDDQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKV  240
 241 DKQQVILDASCSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINEHRHQINDGA  300
 301 AWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGRDFKPNLKVWF  360
 361 GATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTGDVEVPISLVRDDGVVYSSGL  420
 421 TFSYKSL
Interface Residues: 35, 38, 40, 142, 143, 146, 169, 170, 171
3D-footprint Homologues: 3brd_A, 3iag_C, 5e24_E
Binding Motifs: 3brd_A TGGGa
Binding Sites: 3brd_B
3brd_C
			
Publications: Friedmann D.R, Wilson J.J, Kovall R.A. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. The Journal of biological chemistry 283:14781-91 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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