DNA Binding Site

						

			
Accessions: 1ttu_C (3D-footprint 20231221), 2fo1_C (3D-footprint 20231221), 3brd_C (3D-footprint 20231221), 3brf_C (3D-footprint 20231221), 3brg_A (3D-footprint 20231221), 4j2x_E (3D-footprint 20231221), 5e24_G (3D-footprint 20231221), 5eg6_B (3D-footprint 20231221), 6dks_E (3D-footprint 20231221)

			
Organisms: Caenorhabditis elegans, Mus musculus, Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 13
Sequence: TCTTTCCCACAGT
Type: Heterodimer
Binding TFs: 1ttu_A (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
2fo1_A (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
3brf_A (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
3brg_C (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
4j2x_C (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
3brd_A (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
6dks_G (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
5e24_E (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
5eg6_C (IPT/TIG domain, Beta-trefoil DNA-binding domain, LAG1, DNA binding)
Binding Motifs: 1ttu_A tGngA
2fo1_A TTCnCAC
3brd_A TGGGa
3brf_A TGTGGGAA
3brg_C TTCCCACA
4j2x_C TTCCCACA
5e24_E tCCCAc
5eg6_C TGGGAA
6dks_G tTncCA
			
Publications: Kovall R.A, Hendrickson W.A. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. The EMBO journal 23:3441-51 (2004). [Pubmed]


Wilson J.J, Kovall R.A. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell 124:985-96 (2006). [Pubmed]


Friedmann D.R, Wilson J.J, Kovall R.A. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. The Journal of biological chemistry 283:14781-91 (2008). [Pubmed]


Collins K.J, Yuan Z, Kovall R.A. Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling. Structure (London, England : 1993) 22:70-81 (2014). [Pubmed]


Yuan Z, Praxenthaler H, Tabaja N, Torella R, Preiss A, Maier D, Kovall RA. Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS Biol : (2016). [Pubmed]


Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep 26:845-854 (2019). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.