Transcription Factor
| Accessions: | Meis2_DBD (HumanTF 1.0), UP00226A (UniPROBE 20160601) |
| Names: | Homeobox protein Meis2, Meis1-related protein 1, Meis2, MEIS2_MOUSE, A430109D20Rik, Mrg1, myeloid ecotropic viral integration site-related gene 1, Stra10 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P97367 |
| Description: | myeloid ecotropic viral integration site-related gene 1 |
| Notes: | Ensembl ID: ENSMUSG00000027210; DNA-binding domain sequence; TF family: homeodomain+MEIS; Clone source: Hughes lab. |
| Length: | 96 |
| Pfam Domains: | 18-73 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 SPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTI 60 61 LQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQG |
| Interface Residues: | 17, 19, 20, 64, 65, 68, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 5zfz_A, 6fqp_B, 1puf_B, 1le8_A, 1au7_A, 7q3o_C, 4j19_B, 3lnq_A, 6fqq_E, 4xrs_G, 2d5v_B, 6a8r_A, 3rkq_B, 1le8_B, 5flv_I, 2lkx_A, 1fjl_B, 6es3_K, 1mnm_C, 8g87_X, 5hod_A, 3cmy_A, 1k61_B, 4xrm_B |
| Binding Motifs: | UP00226A_1 warsAsCTGTCAAway Meis2_DBD_1 wTGACAg Meis2_DBD_2 TGACAGsTGTCA |
| Binding Sites: | AACTGTCA AATGACAG ACATGTCA ACCTGTCA AGCTGTCA ATCTGTCA ATGACAGC ATGACAGG ATTGACAG CCTGTCAA CCTGTCAC CGCTGTCA CTGTCAAA CTGTCAAC CTGTCACA GCCTGTCA GCTGTCAA GCTGTCAC GGCTGTCA TGACAGCA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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