Transcription Factor

						

			
Accessions: 4zpk_A (3D-footprint 20231221)

			
Names: ARNT protein, ARNT_MOUSE, Aryl hydrocarbon receptor nuclear translocator, Dioxin receptor, nuclear translocator, HIF-1-beta, HIF1-beta, Hypoxia-inducible factor 1-beta
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P53762
Length: 268
Pfam Domains:      5-56 Helix-loop-helix DNA-binding domain
   66-151 PAS fold
  172-245 PAS fold
  174-267 PAS domain
  178-264 PAS fold
Sequence: 
(in bold interface residues)		   1 ERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLSFLT   60
  61 DQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDK  120
 121 LREQLSTSRRSFICRMRCGTPHFVVVHCTGYIKFCLVAIGRLQVTEFISRHNIEGIFTFV  180
 181 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREW  240
 241 LWMRTSSFTFQNPYSDEIEYIICTNTNV
Interface Residues: 5, 7, 8, 9, 11, 12, 15, 16, 42
3D-footprint Homologues: 1a0a_B, 1an4_A, 8osl_O, 6g1l_A, 5gnj_I, 5sy7_B, 4zpk_B, 7d8t_A, 5i50_B, 4h10_A, 7xi3_A, 5v0l_A, 4zpr_B, 7rcu_E, 4h10_B, 5eyo_A, 1am9_A, 7ssa_L, 5nj8_D, 4zpk_A, 8osl_P, 5nj8_C, 7xhv_B, 7xi3_B, 5v0l_B
Binding Motifs: 4zpk_A CGCACG
4zpk_AB ACGTGCG
Binding Sites: 4zpk_C
4zpk_D
			
Publications: Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature 524:303-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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