Transcription Factor
| Accessions: | T061543_1.02 (CISBP 1.02), UP00291A (UniPROBE 20160601), P27705 (JASPAR 2024) |
| Names: | MIG1, T061543_1.02;, CAT4, Regulatory protein CAT4, Regulatory protein MIG1, SSN1, TDS22, YGL035C, MIG1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 504 |
| Pfam Domains: | 54-78 Zinc-finger double domain 68-90 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MQSPYPMTQVSNVDDGSLLKESKSKSKVAAKSEAPRPHACPICHRAFHRLEHQTRHMRIH 60 61 TGEKPHACDFPGCVKRFSRSDELTRHRRIHTNSHPRGKRGRKKKVVGSPINSASSSATSI 120 121 PDLNTANFSPPLPQQHLSPLIPIAIAPKENSSRSSTRKGRKTKFEIGESGGNDPYMVSSP 180 181 KTMAKIPVSVKPPPSLALNNMNYQTSSASTALSSLSNSHSGSRLKLNALSSLQMMTPIAS 240 241 SAPRTVFIDGPEQKQLQQQQNSLSPRYSNTVILPRPRSLTDFQGLNNANPNNNGSLRAQT 300 301 QSSVQLKRPSSVLSLNDLLVGQRNTNESDSDFTTGGEDEEDGLKDPSNSSIDNLEQDYLQ 360 361 EQSRKKSKTSTPTTMLSRSTSGTNLHTLGYVMNQNHLHFSSSSPDFQKELNNRLLNVQQQ 420 421 QQEQHTLLQSQNTSNQSQNQNQNQMMASSSSLSTTPLLLSPRVNMINTAISTQQTPISQS 480 481 DSQVQELETLPPIRSLPLPFPHMD |
| Interface Residues: | 20, 21, 22, 23, 24, 26, 48, 49, 50, 51, 52, 54, 55, 57, 58, 61, 78, 79, 80, 81, 82, 85, 88, 89, 93, 379, 380, 381 |
| 3D-footprint Homologues: | 8ssu_A, 1tf6_A, 7w1m_H, 8cuc_F, 7y3l_A, 7n5w_A, 2kmk_A, 2drp_D, 2gli_A, 5v3j_F, 8gn3_A, 1ubd_C, 7txc_E, 7ysf_A, 6u9q_A, 8h9h_G, 8ssq_A, 2lt7_A, 1tf3_A, 7y3m_I, 6e94_A, 2jpa_A, 7btq_A |
| Binding Motifs: | UP00291A_1 kwawdwAATGCGGGGkrmwwk M0517_1.02 tGyGGGGw MA0337.1 mCCCCrs MA0337.2 CCCCrs |
| Binding Sites: | AACCCCGC AAGCGGGG ACCCCACA ACCCCGCA ACCCCGCG ACGCGGGG ATGCGGGG ATGTGGGG CCCCACAA CCCCACAC CCCCCACA CCCCCGCA CCCCGCAA CCCCGCAC GCGGGGAA GCGGGGGA GCGGGGTA GTGGGGTA TCCCCACA ATCCGGGG |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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