Transcription Factor
| Accessions: | P35452 (JASPAR 2024) |
| Names: | Homeobox protein Hox-4H, Homeobox protein Hox-D12, HXD12_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P35452 |
| Length: | 270 |
| Pfam Domains: | 203-259 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAP 60 61 AQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFA 120 121 PESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAG 180 181 VASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLN 240 241 LSDQQVKIWFQNRRMKKKRVVLREQALALY |
| Interface Residues: | 163, 164, 165, 168, 169, 174, 178, 203, 204, 205, 206, 207, 244, 245, 247, 248, 251, 252, 255, 256, 259 |
| 3D-footprint Homologues: | 1e3o_C, 3d1n_M, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 4xrs_G, 2hos_A, 4cyc_A, 7psx_B, 1b72_A, 5flv_I, 5zjt_E, 4j19_B, 3a01_E, 5hod_A, 1jgg_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 3l1p_A, 1au7_A, 2xsd_C, 1le8_A, 7xrc_C, 1k61_B, 8g87_X, 1o4x_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C |
| Binding Motifs: | MA0873.1 rgTCGTAAAAm MA1958.1 rrsCGGAAGTyGTAAAa MA0873.2 rgTCGTAAAA MA1958.2 CGGAAGTyGTAAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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