Transcription Factor

Accessions: 1ngm_E (3D-footprint 20231221), 1nh2_A (3D-footprint 20231221), 1rm1_A (3D-footprint 20231221), 1ytb_A (3D-footprint 20231221), 1ytf_A (3D-footprint 20231221), 6f41_U (3D-footprint 20231221)
Names: TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP_YEAST, Transcription factor D, Transcription initiation factor TFIID, Transcription initiation factor TFIID TBP subunit, TATA-box binding protein, TATA BINDING PROTEIN (TBP)
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P13393
Length: 180
Pfam Domains: 5-87 Transcription factor TFIID (or TATA-binding protein, TBP)
92-178 Transcription factor TFIID (or TATA-binding protein, TBP)
Sequence:
(in bold interface residues)
1 SGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGK 60
61 MVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHG 120
121 TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM 180
Interface Residues: 9, 11, 39, 40, 54, 56, 62, 64, 98, 99, 101, 130, 131, 145, 147, 153, 155
3D-footprint Homologues: 7z7n_D, 1qna_B, 5n9g_G, 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D, 6cnb_R, 1cdw_A, 5iy6_P
Binding Motifs: 1ngm_E TAtAAaA
1nh2_AC TAnAAaAc
1rm1_A gTtTTATA
1rm1_AC gTtTTATA
1ytb_A GTAtATAAnnCG
1ytf_AC TATATAAAAC
6f41_U AntTnTa
Binding Sites: 1ngm_G
1ngm_H
1nh2_F / 1ytf_F
1rm1_D
1rm1_E
1ytf_E
1ytb_C
1nh2_E
6f41_X
6f41_Y
Publications: Juo Z.S, Kassavetis G.A, Wang J, Geiduschek E.P, Sigler P.B. Crystal structure of a transcription factor IIIB core interface ternary complex. Nature 422:534-9 (2003). [Pubmed]

Bleichenbacher M, Tan S, Richmond T.J. Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. Journal of molecular biology 332:783-93 (2003). [Pubmed]

Kim Y, Geiger J.H, Hahn S, Sigler P.B. Crystal structure of a yeast TBP/TATA-box complex. Nature 365:512-20 (1993). [Pubmed]

Tan S., Hunziker Y., Sargent D. F., Richmond T. J. Crystal structure of a yeast TFIIA/TBP/DNA complex. Nature 381:127-134 (1996). [Pubmed]

Vorländer MK, Khatter H, Wetzel R, Hagen WJH, Müller CW. Molecular mechanism of promoter opening by RNA polymerase III. Nature 553:295-300 (2018). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.