Transcription Factor

						

			
Accessions: 1ngm_E (3D-footprint 20231221), 1nh2_A (3D-footprint 20231221), 1rm1_A (3D-footprint 20231221), 1ytb_A (3D-footprint 20231221), 1ytf_A (3D-footprint 20231221), 6f41_U (3D-footprint 20231221)

			
Names: TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP_YEAST, Transcription factor D, Transcription initiation factor TFIID, Transcription initiation factor TFIID TBP subunit, TATA-box binding protein, TATA BINDING PROTEIN (TBP)
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P13393
Length: 180
Pfam Domains:      5-87 Transcription factor TFIID (or TATA-binding protein, TBP)
   92-178 Transcription factor TFIID (or TATA-binding protein, TBP)
Sequence: 
(in bold interface residues)		   1 SGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGK   60
  61 MVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHG  120
 121 TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM  180
Interface Residues: 9, 11, 39, 40, 54, 56, 62, 64, 98, 99, 101, 130, 131, 145, 147, 153, 155
3D-footprint Homologues: 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D, 6cnb_R, 1cdw_A, 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G
Binding Motifs: 1ngm_E TAtAAaA
1nh2_AC TAnAAaAc
1rm1_A gTtTTATA
1rm1_AC gTtTTATA
1ytb_A GTAtATAAnnCG
1ytf_AC TATATAAAAC
6f41_U AntTnTa
Binding Sites: 1ngm_G
1ngm_H
1nh2_F / 1ytf_F
1rm1_D
1rm1_E
1ytf_E
1ytb_C
1nh2_E
6f41_X
6f41_Y
			
Publications: Juo Z.S, Kassavetis G.A, Wang J, Geiduschek E.P, Sigler P.B. Crystal structure of a transcription factor IIIB core interface ternary complex. Nature 422:534-9 (2003). [Pubmed]


Bleichenbacher M, Tan S, Richmond T.J. Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. Journal of molecular biology 332:783-93 (2003). [Pubmed]


Kim Y, Geiger J.H, Hahn S, Sigler P.B. Crystal structure of a yeast TBP/TATA-box complex. Nature 365:512-20 (1993). [Pubmed]


Tan S., Hunziker Y., Sargent D. F., Richmond T. J. Crystal structure of a yeast TFIIA/TBP/DNA complex. Nature 381:127-134 (1996). [Pubmed]


Vorländer MK, Khatter H, Wetzel R, Hagen WJH, Müller CW. Molecular mechanism of promoter opening by RNA polymerase III. Nature 553:295-300 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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