Transcription Factor
Accessions: | 2it0_C (3D-footprint 20231221), 2it0_D (3D-footprint 20231221) |
Names: | IDER_MYCTU, Iron-dependent repressor ideR |
Organisms: | Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P9WMH0 |
Length: | 137 |
Pfam Domains: | 1-60 Iron dependent repressor, N-terminal DNA binding domain 9-66 Winged helix DNA-binding domain 63-132 Iron dependent repressor, metal binding and dimerisation domain |
Sequence: (in bold interface residues) | 1 ELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDGLLRVAGDRHL 60 61 ELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLVKVLNN 120 121 PTTSPFGNPIPGLVELG |
Interface Residues: | 35, 36, 37, 38, 40, 41, 42, 45, 53, 55, 56 |
3D-footprint Homologues: | 4lln_I, 2isz_B, 6jbx_A, 1ddn_B, 7b24_C, 1f5t_A, 4hf1_A, 1u8r_B, 4fx4_B |
Binding Motifs: | 2it0_ABCD AGGGnAGCCTnnGCT |
Binding Sites: | 2it0_E 2it0_F |
Publications: | Wisedchaisri G, Chou C.J, Wu M, Roach C, Rice A.E, Holmes R.K, Beeson C, Hol W.G. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 46:436-47 (2007). [Pubmed] |
Related annotations: | PaperBLAST |
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