Transcription Factor

						

			
Accessions: 4iqr_B (3D-footprint 20231221)

			
Names: Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, HNF4A_HUMAN, Nuclear receptor subfamily 2 group A member 1, TCF-14, Transcription factor 14, Transcription factor HNF-4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P41235
Length: 308
Pfam Domains:      2-70 Zinc finger, C4 type (two domains)
  110-292 Ligand-binding domain of nuclear hormone receptor
Sequence: 
(in bold interface residues)		   1 ALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRL   60
  61 KKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSDIRAKKIASIADVCE  120
 121 SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY  180
 181 IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIK  240
 241 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL  300
 301 LQEMLLGG
Interface Residues: 11, 12, 14, 15, 21, 22, 24, 25, 28, 29, 53, 75, 77, 79, 81, 82, 84, 86
3D-footprint Homologues: 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A
Binding Motifs: 4iqr_AB GACCtnTKaCC
4iqr_B AGGTCA
Binding Sites: 4iqr_C
4iqr_D
			
Publications: Chandra V, Huang P, Potluri N, Wu D, Kim Y, Rastinejad F. Multidomain integration in the structure of the HNF-4α nuclear receptor complex. Nature 495:394-8 (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.