Transcription Factor

						

			
Accessions: 3nbn_A (3D-footprint 20231221), 3nbn_D (3D-footprint 20231221)

			
Names: CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Recombining binding protein suppressor of hairless, Renal carcinoma antigen NY-REN-30, SUH_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q06330
Length: 423
Pfam Domains:    22-153 LAG1, DNA binding
  154-303 Beta-trefoil DNA-binding domain
  331-419 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 PPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKE   60
  61 QMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKM  120
 121 FYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHV  180
 181 EGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIR  240
 241 KVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDG  300
 301 ASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVW  360
 361 FGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYT  420
 421 PEP
Interface Residues: 35, 38, 40, 140, 141, 144, 169, 170, 171
3D-footprint Homologues: 3brd_A, 3iag_C, 5e24_E
Binding Motifs: 3nbn_AD CTgTGGGAAnnnnnnnnnnnnnnnTTCnCA
3nbn_D TTCnCAnG
Binding Sites: 3nbn_X
3nbn_Y
			
Publications: Arnett K.L, Hass M, McArthur D.G, Ilagan M.X, Aster J.C, Kopan R, Blacklow S.C. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature structural & molecular biology 17:1312-7 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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