Transcription Factor
| Accessions: | HOXA6_TF1 (HumanTF2 1.0), HOXA6 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-1B, Homeobox protein Hox-A6, HOXA6, HXA6_HUMAN, ENSG00000106006 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P31267 |
| Notes: | Ensembl ID: ENSG00000106006; Construct type: TF1(SBP); TF family: Homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 232 |
| Pfam Domains: | 155-211 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGASSLPDKTYTSPCFYQQS 60 61 NSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSSGQGK 120 121 ALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLT 180 181 RRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE |
| Interface Residues: | 155, 156, 157, 158, 159, 196, 197, 199, 200, 203, 204, 206, 207, 208, 211 |
| 3D-footprint Homologues: | 1fjl_B, 1ig7_A, 5zfz_A, 3cmy_A, 4j19_B, 1puf_A, 8ejp_B, 6a8r_A, 8pmf_A, 1nk2_P, 1zq3_P, 2lkx_A, 6m3d_C, 1jgg_B, 3lnq_A, 2ld5_A, 7q3o_C, 5jlw_D, 3rkq_B, 8eml_B, 1b72_A, 6es3_K, 4xrs_G, 3a01_E, 9b8u_A, 4cyc_A, 8ik5_C, 5flv_I, 2hdd_A, 5zjt_E, 2r5y_A, 8osb_E, 7psx_B, 5hod_A, 2hos_A, 1puf_B, 7xrc_C, 1e3o_C, 1le8_A, 2xsd_C, 1o4x_A, 1du0_A, 8bx1_A, 4qtr_D |
| Binding Motifs: | HOXA6 symATTAa HOXA6_3 ggymATTAas HOXA6_methyl_1 bgymATTAas HOXA6_methyl_2 rtCrTTAw |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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