Transcription Factor

						

			
Accessions: UP00094A (UniPROBE 20160601)

			
Names: 9630016P15Rik, MGC113768, mZnf8, Zfp128, zinc finger protein 128
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q52KP6
Description: zinc finger protein 128: Zinc finger protein 128 [Mus musculus]
Length: 263
Pfam Domains:     12-27 Zinc-finger double domain
    15-36 C2H2-type zinc finger
    16-38 C2H2-type zinc finger
    16-38 Zinc finger, C2H2 type
    30-54 Zinc-finger double domain
    44-66 Zinc finger, C2H2 type
    45-66 C2H2-type zinc finger
    46-62 C2H2-type zinc finger
    58-81 Zinc-finger double domain
    71-92 C2H2-type zinc finger
    72-94 Zinc finger, C2H2 type
    72-94 C2H2-type zinc finger
   86-110 Zinc-finger double domain
   99-122 C2H2-type zinc finger
  100-122 Zinc finger, C2H2 type
  100-122 C2H2-type zinc finger
  115-139 Zinc-finger double domain
  127-149 C2H2-type zinc finger
  128-150 C2H2-type zinc finger
  128-150 Zinc finger, C2H2 type
  146-167 Zinc-finger double domain
  155-178 C2H2-type zinc finger
  156-178 C2H2-type zinc finger
  156-178 Zinc finger, C2H2 type
  170-187 Zinc-finger double domain
  226-248 C2H2-type zinc finger
  226-248 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MPITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSLV   60
  61 QHERIHTGDKPYKCDECGKSFCHSTHLTVHRRIHTGEKPYECQDCGRAFNQNSSLGRHKR  120
 121 THTGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYECNHCGKGFRHSSSLAQHQRKHAG  180
 181 EKPYECRQRLIFEQAPALIKYEWTEPLGCDSPLSQGERTQRSDRPFKCNQCGKCFTQSSH  240
 241 LIRHQLTHSREEEPLRGRSRRQE
Interface Residues: 16, 26, 27, 28, 29, 30, 32, 33, 35, 36, 39, 54, 55, 56, 57, 58, 61, 62, 65, 82, 83, 84, 85, 86, 87, 88, 89, 90, 110, 111, 112, 113, 114, 115, 116, 117, 120, 138, 139, 140, 141, 142, 144, 145, 149, 167, 168, 169, 170, 173, 176, 189, 210, 211, 212, 215, 221, 235, 237, 239, 240, 243, 247
3D-footprint Homologues: 2kmk_A, 1tf3_A, 7w1m_H, 5yel_A, 5ei9_F, 1mey_C, 6wmi_A, 2i13_A, 6e94_A, 2jpa_A, 6jnm_A, 2gli_A, 8ssq_A, 1tf6_A, 6ml4_A, 5v3j_F, 4x9j_A, 5kkq_D, 8ssu_A, 7txc_E, 4m9v_C, 7eyi_G, 7ysf_A, 6a57_A, 1ubd_C, 8cuc_F, 1g2f_F, 6blw_A, 6u9q_A, 5kl3_A, 5und_A, 2lt7_A, 7y3l_A, 7n5w_A, 3uk3_C, 1llm_D, 2wbs_A, 8gn3_A, 2drp_D, 1f2i_J, 5k5i_A, 8h9h_G, 8gh6_A, 7y3m_I, 5k5l_F, 5yj3_D
Binding Motifs: UP00094A_1 khwdkGGCGTACccyaa
UP00094A_2 kkTATAywTATAmc
Binding Sites: ACGTACGC
AGCGTACG
AGGCGTAC
AGTACGCC
ATGCGTAC
CGTACGCA
CGTACGCC
CGTACGTC
GACGTACC
GCGTACCA
GGACGTAC
GGCGTACA
GGCGTACC
GGGCGTAC
GGTACGAC
GGTACGCA
GTACGACA
GTACGCCA
GTACGTCA
AGTCGTAC
			
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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