Transcription Factor

						

			
Accessions: 4f6m_A (3D-footprint 20231221), 6df5_A (3D-footprint 20231221)

			
Names: KAISO_HUMAN, Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q86T24
Length: 116
Pfam Domains:     27-50 Zinc-finger double domain
    41-63 C2H2-type zinc finger
    57-79 Zinc-finger double domain
    69-92 C2H2-type zinc finger
    69-92 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 DHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKHE   60
  61 IHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQY
Interface Residues: 13, 23, 24, 25, 26, 27, 29, 30, 32, 33, 36, 51, 52, 53, 54, 55, 56, 57, 58, 59, 79, 80, 81, 82, 83, 84, 85, 86, 87, 90, 114, 116
3D-footprint Homologues: 2kmk_A, 7n5w_A, 6jnm_A, 1tf3_A, 6ml4_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 6e94_A, 5kl3_A, 1ubd_C, 7ysf_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 7eyi_G, 5k5i_A, 8ssu_A, 2gli_A, 8h9h_G, 5v3j_F, 2lt7_A, 6a57_A, 8gn3_A, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 5yel_A, 1llm_D, 7txc_E, 2wbs_A, 1f2i_J, 4m9v_C, 7y3m_I, 5yj3_D
Binding Motifs: 4f6m_A tCCTGCCA
6df5_A tGGCAGGa
Binding Sites: 4f6m_D
4f6m_E
6df5_D
6df5_E
			
Publications: Buck-Koehntop B.A, Stanfield R.L, Ekiert D.C, Martinez-Yamout M.A, Dyson H.J, Wilson I.A, Wright P.E. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proceedings of the National Academy of Sciences of the United States of America 109:15229-34 (2012). [Pubmed]


Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences. Biochemistry 59:1909-1926 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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