Transcription Factor

						

			
Accessions: UP00037A (UniPROBE 20160601)

			
Names: Not Available, Zfp105, zinc finger protein 105
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q3UHV1
Description: zinc finger protein 105: Mus musculus zinc finger protein 105 (Zfp105)
Length: 321
Pfam Domains:      8-26 Zinc-finger double domain
    15-36 C2H2-type zinc finger
    16-38 C2H2-type zinc finger
    16-38 Zinc finger, C2H2 type
    30-53 Zinc-finger double domain
    43-62 C2H2-type zinc finger
    44-66 Zinc finger, C2H2 type
    58-83 Zinc-finger double domain
    72-94 C2H2-type zinc finger
    72-92 C2H2-type zinc finger
    72-94 Zinc finger, C2H2 type
   86-111 Zinc-finger double domain
   99-122 C2H2-type zinc finger
  100-122 C2H2-type zinc finger
  100-122 Zinc finger, C2H2 type
  115-139 Zinc-finger double domain
  128-148 C2H2-type zinc finger
  128-150 Zinc finger, C2H2 type
  128-150 C2H2-type zinc finger
  142-167 Zinc-finger double domain
  156-178 C2H2-type zinc finger
  156-178 Zinc finger, C2H2 type
  156-178 C2H2-type zinc finger
  170-195 Zinc-finger double domain
  183-204 C2H2-type zinc finger
  184-206 Zinc finger, C2H2 type
  184-206 C2H2-type zinc finger
  199-222 Zinc-finger double domain
  212-234 C2H2-type zinc finger
  212-232 C2H2-type zinc finger
  212-234 Zinc finger, C2H2 type
  229-251 Zinc-finger double domain
  240-262 C2H2-type zinc finger
  240-254 C2H2-type zinc finger
  240-262 Zinc finger, C2H2 type
  255-278 Zinc-finger double domain
  268-290 C2H2-type zinc finger
  268-290 C2H2-type zinc finger
  268-290 Zinc finger, C2H2 type
  282-305 Zinc-finger double domain
  295-307 C2H2-type zinc finger
  296-318 C2H2-type zinc finger
  296-318 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 STPGKNQKIQPGQKPFTCSECGKGFSQSANLVVHQRIHTGEKPFECHECGKAFIQSANLV   60
  61 VHQRIHTGQKPYVCGKCGKAFTQSSNLTVHQKIHSLEKTFKCSECEKAFSYSSQLARHQK  120
 121 VHITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFACSDCDKAFTQSANLIVHQRSHTG  180
 181 EKPYKCKDCEKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPY  240
 241 VCNECGKAFTCSSYLLIHQRIHNGEKPYSCNECGKAFRQRSSLTVHQRTHTGEKPYECAK  300
 301 CGAAFISNSHLMRHHRTHLVE
Interface Residues: 5, 7, 8, 16, 27, 28, 29, 30, 33, 37, 54, 55, 56, 57, 58, 60, 61, 64, 82, 83, 84, 85, 86, 89, 93, 110, 111, 112, 113, 114, 116, 117, 138, 139, 140, 141, 142, 144, 145, 147, 148, 151, 166, 167, 168, 169, 170, 173, 177, 194, 195, 196, 197, 198, 199, 201, 204, 222, 223, 224, 225, 226, 228, 229, 235, 249, 250, 251, 252, 253, 254, 256, 257, 261, 278, 279, 280, 281, 282, 284, 285, 286, 307, 308, 309, 310, 311, 312, 313, 314
3D-footprint Homologues: 1tf6_A, 2kmk_A, 4x9j_A, 1llm_D, 5kkq_D, 1ubd_C, 1mey_C, 1f2i_J, 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 1g2f_F, 8ssu_A, 6e94_A, 7txc_E, 6ml4_A, 5yel_A, 7n5w_A, 5v3j_F, 8gn3_A, 2drp_D, 8h9h_G, 7eyi_G, 7ysf_A, 8cuc_F, 7y3l_A, 2i13_A, 6blw_A, 6u9q_A, 2gli_A, 5k5l_F, 7y3m_I, 2jpa_A, 1tf3_A, 2wbs_A, 5kl3_A, 6wmi_A, 5ei9_F, 3uk3_C, 6jnm_A, 2lt7_A, 6a57_A, 4m9v_C, 5yj3_D
Binding Motifs: UP00037A_1 wayAAwhAAmAAkar
UP00037A_2 dyggkTCAATAAytykr
Binding Sites: AAAAACAA
AAACAACA
AAATAAAA
AAATAACA
AACAAATA
AACAACAA
ACAAATAA
ATAAACAA
ATCAACAA
ATCAATAA
CAAACAAC
CAAATAAC
CAACAAAA
GCAAACAA
GCAAATAA
GTTATTGA
TAAATAAA
TCAACAAA
TTATTGAA
AAAAAAAA
			
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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