Transcription Factor
| Accessions: | 1a1l_A (3D-footprint 20231221), 1aay_A (3D-footprint 20231221), 1zaa_C (3D-footprint 20231221) |
| Names: | Early growth response protein 1, EGR-1, EGR1_MOUSE, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, ZIF268 ZINC FINGER PEPTIDE, Zinc finger protein Krox-24, ZIF268 |
| Organisms: | Mus musculus |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P08046 |
| Length: | 85 |
| Pfam Domains: | 3-27 C2H2-type zinc finger 3-27 Zinc finger, C2H2 type 20-43 Zinc-finger double domain 33-55 C2H2-type zinc finger 33-55 Zinc finger, C2H2 type 47-71 Zinc-finger double domain 61-83 Zinc finger, C2H2 type 61-79 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKP 60 61 FACDICGRKFARSDERKRHTKIHLR |
| Interface Residues: | 15, 16, 17, 18, 19, 21, 22, 43, 44, 45, 46, 47, 49, 50, 51, 71, 72, 73, 74, 75, 76, 77, 78, 79 |
| 3D-footprint Homologues: | 6jnm_A, 7n5w_A, 1tf3_A, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 2i13_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 2jpa_A, 1mey_C, 5kl3_A, 7ysf_A, 1f2i_J, 6wmi_A, 2kmk_A, 8ssq_A, 7w1m_H, 7eyi_G, 5v3j_F, 8h9h_G, 2lt7_A, 6e94_A, 6a57_A, 8cuc_F, 7y3l_A, 3uk3_C, 1llm_D, 2wbs_A, 5yel_A, 7txc_E, 2drp_D, 5k5i_A, 4m9v_C, 7y3m_I, 8gn3_A, 5yj3_D |
| Binding Motifs: | 1a1l_A GCCCaCGC 1aay_A aCGCCCaCGC 1zaa_C ACGCCCACGC |
| Binding Sites: | 1aay_B / 1zaa_A 1aay_C / 1zaa_B 1a1l_B 1a1l_C |
| Publications: | Elrod-Erickson M, Benson T.E, Pabo C.O. High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition. Structure (London, England : 1993) 6:451-64 (1998). [Pubmed] Elrod-Erickson M, Rould M.A, Nekludova L, Pabo C.O. Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions. Structure (London, England : 1993) 4:1171-80 (1996). [Pubmed] Pavletich N. P., Pablo C. O. Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A. Science 252:809-816 (1991). [Pubmed] |
| Related annotations: | PaperBLAST |
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