Transcription Factor
| Accessions: | 6erp_C (3D-footprint 20231221), 6erp_G (3D-footprint 20231221), 6erq_C (3D-footprint 20231221), 6erq_G (3D-footprint 20231221) |
| Names: | Mitochondrial transcription factor 1, MtTF1, mtTFA, TCF-6, TFAM_HUMAN, Transcription factor 6, Transcription factor 6-like 2, Transcription factor A, mitochondrial |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q00059 |
| Length: | 192 |
| Pfam Domains: | 8-70 Domain of unknown function (DUF1898) 8-76 HMG (high mobility group) box 112-173 Domain of unknown function (DUF1898) 113-176 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 SSVLASSPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDA 60 61 YRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAY 120 121 NVYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQM 180 181 IEVGRKDLLRRT |
| Interface Residues: | 10, 13, 15, 16, 19, 23, 34, 35, 36, 39, 97, 98, 99, 101, 104, 105, 115, 120, 121, 124, 128, 136, 137, 140 |
| 3D-footprint Homologues: | 2gzk_A, 3u2b_C, 1j5n_A, 3f27_D, 4y60_C, 1o4x_B, 3tmm_A, 6jrp_D, 1qrv_A, 3tq6_B, 1hry_A, 7zie_A, 1ckt_A |
| Binding Motifs: | 6erp_ACF TAGTTGGnnnnnnnCTGTTnnnnnnnnnnnnCnT 6erp_BGJ AGTTGGnnnnnnnCTGTTnnnnnnnnnnnnCnTG 6erq_ACF GGTnTnnnnnnnnnnGGGTAnnnnnnnAGCAGCG 6erq_BGJ GCTGCTnnnnnnnTACCCnnnnnnnnnnnnATAG |
| Binding Sites: | 6erp_D / 6erp_H 6erp_E / 6erp_I 6erq_D / 6erq_H 6erq_E / 6erq_I |
| Publications: | Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P. Structural Basis of Mitochondrial Transcription Initiation. Cell 171:1072-1081 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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