Transcription Factor
| Accessions: | IRF3 (HT-SELEX2 May2017) |
| Names: | ENSG00000126456, IRF3 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: IRF experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: IRF experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: IRF experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3, TF family: IRF experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 128 |
| Pfam Domains: | 5-109 Interferon regulatory factor transcription factor |
| Sequence: (in bold interface residues) | 1 TPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATG 60 61 AYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDT 120 121 SPDTNGGG |
| Interface Residues: | 38, 40, 72, 76, 77, 79, 80, 83, 84 |
| 3D-footprint Homologues: | 2o61_A, 2pi0_B, 1if1_B, 2irf_L, 7oot_B |
| Binding Motifs: | IRF3_2 kCrGTTTCsvsGAAACcGaAAcy IRF3_4 agGAAAcsGAAACcGAAACw IRF3_methyl_1 kCdGTTTCCwGGAAAcyrAaAc IRF3_methyl_3 mGGAAAggGAAAsbGAAAsw |
| Related annotations: | PaperBLAST |
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