Transcription Factor
| Accessions: | UP00066A (UniPROBE 20160601) |
| Names: | alpha, D19Mgi10, hepatic nuclear factor 4, Hepatocyte nuclear factor 4-alpha, Hnf-4, HNF-4-alpha, HNF4 alpha, Hnf4a, MODY1, Nr2a1, Nuclear receptor 2A1, Tcf14, Tcf4, Transcription factor 14, Transcription factor HNF-4 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P49698 |
| Description: | hepatic nuclear factor 4, alpha: Mus musculus hepatic nuclear factor 4, alpha (Hnf4a), mRNA |
| Length: | 107 |
| Pfam Domains: | 18-86 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ 60 61 CVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSS |
| Interface Residues: | 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 69, 91, 93, 95, 98 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B |
| Binding Motifs: | UP00066A_1 skymmGGGGTCAAytkm UP00066A_2 kkchAAAGTCCAmthw |
| Binding Sites: | AAAGGTCA AAAGTCCA AAGTCCAA AGAGTCCA AGGGGTCA AGGGTCAA AGGGTCCA ATGACCCC ATGGACCC CGGGGTCA CGGGTCCA CTGACCCC GAGTCCAA GGGGTCAA GGGTCAAA GGGTCAAC GGGTCCAA GGGTCCAC TGACCCCA TGGACCCA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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