Transcription Factor
| Accessions: | UP00066A (UniPROBE 20160601) |
| Names: | alpha, D19Mgi10, hepatic nuclear factor 4, Hepatocyte nuclear factor 4-alpha, Hnf-4, HNF-4-alpha, HNF4 alpha, Hnf4a, MODY1, Nr2a1, Nuclear receptor 2A1, Tcf14, Tcf4, Transcription factor 14, Transcription factor HNF-4 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P49698 |
| Description: | hepatic nuclear factor 4, alpha: Mus musculus hepatic nuclear factor 4, alpha (Hnf4a), mRNA |
| Length: | 107 |
| Pfam Domains: | 18-86 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ 60 61 CVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSS |
| Interface Residues: | 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 69, 91, 93, 95, 98 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | UP00066A_1 skymmGGGGTCAAytkm UP00066A_2 kkchAAAGTCCAmthw |
| Binding Sites: | AAAGGTCA AAAGTCCA AAGTCCAA AGAGTCCA AGGGGTCA AGGGTCAA AGGGTCCA ATGACCCC ATGGACCC CGGGGTCA CGGGTCCA CTGACCCC GAGTCCAA GGGGTCAA GGGTCAAA GGGTCAAC GGGTCCAA GGGTCCAC TGACCCCA TGGACCCA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.