Transcription Factor
| Accessions: | Meis3_DBD (HumanTF 1.0), UP00210A (UniPROBE 20160601) |
| Names: | Homeobox protein Meis3, Meis1-related protein 2, Meis3, MEIS3_MOUSE, AI573393, Mrg2, myeloid ecotropic viral integration site-related gene 2 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P97368 |
| Description: | myeloid ecotropic viral integration site-related gene 2 |
| Notes: | Ensembl ID: ENSMUSG00000041420; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 96 |
| Pfam Domains: | 18-73 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 PSSAGEDEDLDLERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTI 60 61 LQVNNWFINARRRIVQPMIDQSNRTGQGASFNPEGQ |
| Interface Residues: | 17, 19, 20, 64, 65, 68, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 6fqp_B, 1puf_B, 4j19_B, 1le8_A, 1au7_A, 7q3o_C, 6es3_K, 1mnm_C, 8g87_X, 5hod_A, 3cmy_A, 1k61_B, 4xrm_B, 5zfz_A, 3lnq_A, 6fqq_E, 4xrs_G, 2d5v_B, 6a8r_A, 3rkq_B, 1le8_B, 5flv_I, 2lkx_A, 1fjl_B |
| Binding Motifs: | UP00210A_1 wadbAsCTGTCAwwmc Meis3_DBD_1 tTGACAg Meis3_DBD_2 TGACAGsTGTCA |
| Binding Sites: | AATGACAG ACATGTCA AGCTGTCA ATCTGTCA ATGACAGC ATGACAGG ATTGACAG CCTGTCAA CCTGTCAC CCTGTCAG CGCTGTCA CTGACAGC CTGTCAAA CTGTCACA GCCTGTCA GCTGTCAA GCTGTCAC GGCTGTCA TCCTGTCA TGACAGCA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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