Transcription Factor
| Accessions: | UP00277A (UniPROBE 20160601) |
| Names: | L9324.1, Leu3, Regulatory protein LEU3, YLR451W |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P08638 |
| Description: | Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in ... |
| Length: | 126 |
| Pfam Domains: | 35-74 Fungal Zn(2)-Cys(6) binuclear cluster domain |
| Sequence: (in bold interface residues) | 1 EGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCA 60 61 KKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNF 120 121 TKEKVK |
| Interface Residues: | 30, 40, 42, 43, 44, 45, 61, 62, 74 |
| 3D-footprint Homologues: | 1f5e_P, 1pyi_A, 2er8_C, 1zme_D |
| Binding Motifs: | UP00277A_1 tcmawwACCGGcGwawkctar |
| Binding Sites: | AACCGGAG AACCGGCG AACTCCGG AATACCGG ACCGGAAC ACCGGAGA ACCGGAGT ACCGGCAT ACCGGCGA ACCGGCGT ACCGGGAT ACTCCGGA CACCGGAA CGCCGGTA CTCCGGAG TTCCGGAA AATCCCGG ATTACCGG CCGGCCGG GACCGGTC |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] |
| Related annotations: | PaperBLAST |
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