DNA Binding Motif

						

			
Accessions: TFAP2C_HES7_1 (HumanTF2 1.0)

			
Names: TFAP2C_HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 24
Consensus: srCaCGyGycsyrtssCCysrGGs
Weblogo: 
PSSM: P0      A      C      G      T
01   3748   5877   9753   3871      s
02   6483   5247   9829   1691      r
03   1035  23249    701    605      C
04  17070    854   6179   1168      a
05    241  23249    135   2348      C
06   2194    644  23249    462      G
07    935   7457    831  15792      y
08    965   1740  23249   1865      G
09   2429  10824   3782   6214      y
10   3135  12091   4415   3608      c
11   5419   6478   6627   4725      s
12   4485   8160   4662   5941      y
13   7245   4795   6047   5162      r
14   4906   5122   4689   8532      t
15   4059   7517   6617   5056      s
16   1537   8986  14263    805      s
17    187  23249   1442    638      C
18    653  23249   2033   7308      C
19   1584   7125   4647   9893      y
20   4200   7596   7909   3544      s
21  10134   4496   7387   1232      r
22   6386    994  23249    257      G
23    489   3174  23249    305      G
24   1139  13958   9291   1562      s
Type: Heterodimer
Binding TFs: HES7_TF2 (Helix-loop-helix DNA-binding domain)
TFAP2C_TF1 (Transcription factor AP-2)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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