DNA Binding Motif

						

			
Accessions: HOXB2_NHLH1_2_3 (HumanTF2 1.0)

			
Names: HOXB2_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: dymrTywkyrkkmkCAGCTGCk
Weblogo: 
PSSM: P0      A      C      G      T
01     63     28     65     69      d
02     79     97     82    128      y
03    132     93     38     38      m
04    225     21    122     40      r
05     15     19     26    225      T
06     54    118     22    225      y
07    225     37      9     99      w
08     53     33     62     76      k
09     19    111     28     68      y
10     67     20    106     33      r
11     40     16     93     77      k
12     30     21    103     71      k
13     78    118     31      0      m
14     20     22    122     60      k
15      4    225      0      2      C
16    225     13      0     14      A
17      0     34    225     13      G
18     16    225     35      9      C
19     24      0      0    225      T
20      0      6    225      0      G
21     37    169      0     37      C
22      1      0    124    116      k
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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