Transcription Factor
| Accessions: | NHLH1_DBD (HumanTF 1.0), NHLH1_TF2 (HumanTF2 1.0) |
| Names: | cDNA, FLJ94293, Homo sapiens nescient helix loop helix 1 (NHLH1, Nescient helix loop helix 1, NHLH1, Q5T203_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q5T203 |
| Notes: | Ensembl ID: ENSG00000171786; DNA-binding domain sequence; TF family: bHLH; Clone source: MGC, Ensembl ID: ENSG00000171786; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013 |
| Length: | 88 |
| Pfam Domains: | 32-82 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MAPEPGEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTL 60 61 PPDKKLSKIEILRLAICYISYLNHVLDV |
| Interface Residues: | 32, 35, 36, 38, 39, 40, 42, 43, 46, 49, 50, 53 |
| 3D-footprint Homologues: | 7z5k_B, 1am9_A, 6od3_F, 4h10_A, 4h10_B, 8osl_O, 8osl_P, 2ypa_B, 2ql2_A, 2ypa_A, 2ql2_D, 5d8c_A |
| Binding Motifs: | NHLH1_DBD CGCAGCTGCs CLOCK_NHLH1_1 cgCAGsTGckmcvrCACGTGbm CLOCK_NHLH1_2 mgCAgcTGyscmvCACGTGbm CUX1_NHLH1_1 cGCAGCTGCkcmmamwATyGATy CUX1_NHLH1_2 mgCAGCTGCkcymmytyATyGATc E2F1_NHLH1 sGCGCswyrmygkkgcmGCAGCTGCk ERF_NHLH1 aGCAGCTGCCGGAWrym ETV2_NHLH1_1 mGCAGCTGCCGGAWgyw ETV2_NHLH1_2 wcmGGAwgkramGCAGCTGCk GCM1_NHLH1_1 gCAGCTGykwsmsbrtGcgGG GCM1_NHLH1_2 gCAGsTGykgyysrTrmGGG HOXB2_NHLH1_1 stvaTTakgmmGCAGCTGCG HOXB2_NHLH1_2 ryvaTywrsgyCgCAGCTGCk HOXB2_NHLH1_2_3 dymrTywkyrkkmkCAGCTGCk |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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