DNA Binding Motif

						

			
Accessions: 1o4x_AB (3D-footprint 20231221)

			
Names: transcription factor Oct-1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Length: 16
Consensus: CATTnGCATGACAAAG
Weblogo: 
PSSM: P0      A      C      G      T
01      0     96      0      0      C
02     89      0      7      0      A
03      0      0      0     96      T
04      6      6      9     75      T
05     24     24     24     24      n
06      6      6     75      9      G
07      0     96      0      0      C
08     96      0      0      0      A
09      9      6      6     75      T
10      9      6     75      6      G
11     96      0      0      0      A
12      0     96      0      0      C
13     96      0      0      0      A
14     96      0      0      0      A
15     96      0      0      0      A
16      0      0     96      0      G
Type: Heterodimer
Binding TFs: 1o4x_A (Homeobox domain, Pou domain - N-terminal to homeobox domain)
1o4x_B (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 1o4x_C
1o4x_D
			
Publications: Williams D.C, Cai M, Clore G.M. Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex. The Journal of biological chemistry 279:1449-57 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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