Transcription Factor

						

			
Accessions: 1o4x_B (3D-footprint 20231221), 6ht5_D (3D-footprint 20231221)

			
Names: SOX2_HUMAN, Transcription factor SOX-2, SOX2_MOUSE
Organisms: Homo sapiens, Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P48431
Length: 77
Pfam Domains:      2-63 Domain of unknown function (DUF1898)
     3-71 HMG (high mobility group) box
Sequence: 
(in bold interface residues)		   1 DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLR   60
  61 ALHMKEHPDYKYRPRRK
Interface Residues: 5, 8, 10, 11, 12, 14, 18, 22, 29, 30, 31, 34, 72, 76
3D-footprint Homologues: 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 3tq6_B, 1ckt_A, 1hry_A, 7zie_A
Binding Motifs: 1o4x_AB CATTnGCATGACAAAG
1o4x_B gCAAAG
6ht5_DE CATTGTTATGC
Binding Sites: 1o4x_C
1o4x_D
			
Publications: Williams D.C, Cai M, Clore G.M. Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex. The Journal of biological chemistry 279:1449-57 (2004). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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