DNA Binding Motif

						

			
Accessions: TFAP2C_E2F8 (HumanTF2 1.0)

			
Names: TFAP2C_E2F8
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 19
Consensus: ttTCCCGCbmsCCcsmGGs
Weblogo: 
PSSM: P0      A      C      G      T
01    340    397    378   1047      t
02    258    530     92   1283      t
03    213    410    158   2162      T
04    202   2162    134      0      C
05     59   2162    204     39      C
06      0   2162     28      5      C
07     61    120   2162    234      G
08    103   2162     88    120      C
09     97    660    615    790      b
10    684    764    198    516      m
11    144    802   1188     28      s
12     24   2162     22     23      C
13     46   2162      5    238      C
14    139   1176    327    521      c
15    281    842    808    231      s
16   1080    616    422     45      m
17    386     61   2162     31      G
18     25    134   2162      0      G
19     68   2162    991     84      s
Type: Heterodimer
Binding TFs: E2F8_TF2 (E2F/DP family winged-helix DNA-binding domain)
TFAP2C_TF1 (Transcription factor AP-2)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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