DNA Binding Motif
| Accessions: | 5jvt_AD (3D-footprint 20231221) |
| Names: | Friend leukemia integration 1 transcription factor |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Description: | Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG |
| Length: | 16 |
| Consensus: | TTCCGnnGgnnCGGAa |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 11 5 11 69 T 02 0 0 0 96 T 03 0 96 0 0 C 04 0 96 0 0 C 05 0 0 96 0 G 06 24 24 24 24 n 07 24 24 24 24 n 08 5 16 70 5 G 09 13 16 56 11 g 10 24 24 24 24 n 11 24 24 24 24 n 12 0 96 0 0 C 13 0 0 96 0 G 14 0 0 96 0 G 15 96 0 0 0 A 16 63 11 11 11 a |
| Type: | Heterodimer |
| Binding TFs: | 5jvt_D (Ets-domain) 5jvt_A (Ets-domain) |
| Binding Sites: | 5jvt_B / 5jvt_E 5jvt_C / 5jvt_F |
| Publications: | Hou C, Weidenbach S, Cano KE, Wang Z, Mitra P, Ivanov DN, Rohr J, Tsodikov OV. Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res 44:8990-9004 (2016). [Pubmed] |
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