DNA Binding Motif

						

			
Accessions: ZNF740_4 (HT-SELEX2 May2017), MA0753.2 (JASPAR 2024)

			
Names: ZNF740
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 13
Consensus: cyrCCCCCCCCAc
Weblogo: 
PSSM: P0      A      C      G      T
01    186    502    182    185      c
02    162    677     72    378      y
03    727    343   1055    312      r
04     60   1055     37     49      C
05    110   1055     14      1      C
06     18   1055      4     16      C
07     22   1055      7     15      C
08     23   1055      3     11      C
09     10   1055      7      6      C
10      2   1055      3      3      C
11    115   1055      6      4      C
12   1055    239     68    134      A
13    207   1055     54    246      c
Type: Heterodimer
Binding TFs: ZNF740 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8NDX6 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8NDX6
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Weirauch MT, Cote A, Norel R, Annala M, Zhao Y, Riley TR, Saez-Rodriguez J, Cokelaer T, Vedenko A, Talukder S; DREAM5 Consortium, Bussemaker HJ, Morris QD, Bulyk ML, Stolovitzky G, Hughes TR. Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol 31:126-34 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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