DNA Binding Motif

						

			
Accessions: 2isz_ABCD (3D-footprint 20231221)

			
Names: Iron-dependent repressor ideR
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a two-domain IdeR-DNA complex crystal form I
Length: 15
Consensus: AGnanAGGCTnCCCt
Weblogo: 
PSSM: P0      A      C      G      T
01     85      5      6      0      A
02      5     11     75      5      G
03     24     24     24     24      n
04     65     10     11     10      a
05     24     24     24     24      n
06     96      0      0      0      A
07      0      0     96      0      G
08      0      0     96      0      G
09      0     96      0      0      C
10      0      0      0     96      T
11     24     24     24     24      n
12      5     80      5      6      C
13      0     96      0      0      C
14      0     86      0     10      C
15     11     10     10     65      t
Binding TFs: 2isz_A / 2isz_B / 2isz_C / 2isz_D (Iron dependent repressor, N-terminal DNA binding domain, Iron dependent repressor, metal binding and dimerisation domain, Winged helix DNA-binding domain)
Binding Sites: 2isz_E
2isz_F
			
Publications: Wisedchaisri G, Chou C.J, Wu M, Roach C, Rice A.E, Holmes R.K, Beeson C, Hol W.G. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 46:436-47 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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