DNA Binding Motif

						

			
Accessions: ETV2_DRGX_1 (HumanTF2 1.0), MA1940.1 (JASPAR 2024)

			
Names: ETV2_DRGX, ETV2::DRGX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rsCGGAWryaATTA
Weblogo: 
PSSM: P0      A      C      G      T
01    963    214    603    300      r
02    505    985    581    162      s
03    409   1566     67      2      C
04      0      5   1566      0      G
05      0      2   1566      4      G
06   1566      7      6     13      A
07   1566     94     23    600      W
08    416    235    870     45      r
09     50    730     98    836      y
10   1566    250    380    220      a
11   1566    165    137    122      A
12     10     26     22   1566      T
13    163    178     47   1566      T
14   1566     43     73    233      A
Type: Heterodimer
Binding TFs: DRGX_TF2 (Homeobox domain)
ETV2_TF1 (Ets-domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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