DNA Binding Motif

						

			
Accessions: E2F1_DBD_2 (HumanTF 1.0), MA0024.3 (JASPAR 2024)

			
Names: E2F1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; Possibly partial, HT-SELEX
Length: 12
Consensus: tttGGCGCCaaa
Weblogo: 
PSSM: P0      A      C      G      T
01    254    115     89    565      t
02    241     46    100    638      t
03    208     36    145    627      t
04     54     71    888      1      G
05      0     32    950      0      G
06      0    599      0      2      C
07      0      1   1009      0      G
08      2    588     17      0      C
09      0    577     46     50      C
10    524    171     20    119      a
11    510     80     58    182      a
12    493     59    112    219      a
Type: Heterodimer
Binding TFs: Q01094 (E2F/DP family winged-helix DNA-binding domain)
E2F1_DBD (E2F/DP family winged-helix DNA-binding domain)
Q01094
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Tao Y., Kassatly R. F., Cress W. D., Horowitz J. M. Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17:6994-7007 (1997). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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