DNA Binding Motif

Accessions: 4ond_EF (3D-footprint 20231221)
Names: Ancestral SR2 Helix Mutant
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex
Length: 14
Consensus: GGTCAnnnTGACCT
Weblogo:
PSSM: P0 A C G T
01 2 5 87 2 G
02 0 0 96 0 G
03 5 2 2 87 T
04 13 68 2 13 C
05 96 0 0 0 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 0 0 0 96 T
10 13 10 68 5 G
11 79 13 2 2 A
12 2 90 2 2 C
13 2 90 2 2 C
14 2 2 2 90 T
Binding TFs: 4ond_E / 4ond_F (Zinc finger, C4 type (two domains))
Binding Sites: 4ond_K
4ond_L
Publications: McKeown A.N, Bridgham J.T, Anderson D.W, Murphy M.N, Ortlund E.A, Thornton J.W. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell 159:58-68 (2014). [Pubmed]

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