DNA Binding Motif

						

			
Accessions: 4ond_EF (3D-footprint 20231221)

			
Names: Ancestral SR2 Helix Mutant
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex
Length: 14
Consensus: GGTCAnnnTGACCT
Weblogo: 
PSSM: P0      A      C      G      T
01      2      5     87      2      G
02      0      0     96      0      G
03      5      2      2     87      T
04     13     68      2     13      C
05     96      0      0      0      A
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09      0      0      0     96      T
10     13     10     68      5      G
11     79     13      2      2      A
12      2     90      2      2      C
13      2     90      2      2      C
14      2      2      2     90      T
Binding TFs: 4ond_E / 4ond_F (Zinc finger, C4 type (two domains))
Binding Sites: 4ond_K
4ond_L
			
Publications: McKeown A.N, Bridgham J.T, Anderson D.W, Murphy M.N, Ortlund E.A, Thornton J.W. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell 159:58-68 (2014). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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