DNA Binding Motif

						

			
Accessions: ETV2_SPDEF (HumanTF2 1.0), UN0520.1 (JASPAR 2024)

			
Names: ETV2_SPDEF, ETV2::SPDEF
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 19
Consensus: vsMGGAmGGAwrTCCGsyt
Weblogo: 
PSSM: P0      A      C      G      T
01   5202   5784   7466   2335      v
02   5923  10910   7770    972      s
03   8698  19289    303     33      M
04      9     14  20784     28      G
05      0     42  20783     42      G
06  20660    179    123     34      A
07   9418  19079     21     50      m
08     43      0  20787      2      G
09      8     13  20783     41      G
10  20770     17      9      7      A
11  10270   5331     21   7911      w
12  17880    208  12436    203      r
13      3     13     24  20775      T
14     23  20774     12     12      C
15     19  20771      9     14      C
16     23   1057  19505   6693      G
17    152  10203  10147   6278      s
18   2269   8289   3924   6305      y
19   8690   5601   3471  18330      t
Type: Heterodimer
Binding TFs: SPDEF_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
ETV2_TF1 (Ets-domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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