Transcription Factor

						

			
Accessions: SPDEF_full (HumanTF 1.0), SPDEF_TF2 (HumanTF2 1.0)

			
Names: Prostate epithelium-specific Ets transcription factor, Prostate-derived Ets factor, Prostate-specific Ets, SAM pointed domain-containing Ets transcription factor, SPDEF, SPDEF_HUMAN, ANDR_HUMAN, Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: O95238
Notes: Ensembl ID: ENSG00000124664; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000124664; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 336
Pfam Domains:   132-212 Sterile alpha motif (SAM)/Pointed domain
  249-333 Ets-domain
Sequence: 
(in bold interface residues)		   1 MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWSPSPPATPEQGLSAFYL   60
  61 SYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPAGSLDLVPGGLTLEEHSLE  120
 121 QVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAG  180
 181 KELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKERTSPGAIHYCASTSEESWTDSEV  240
 241 DSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAM  300
 301 NYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI*
Interface Residues: 245, 303, 304, 306, 307, 308, 310, 311, 326
3D-footprint Homologues: 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: SPDEF_full_1 AmCCGGATgTr
SPDEF_full_2 gkGGTCCCGGATyAt
SPDEF_full_3 gCAGwAAGAmGTAWmm
ELK1_SPDEF mcmGGAmGGAwATCCKgg
ETV2_SPDEF vsMGGAmGGAwrTCCGsyt
FOXO1_SPDEF wvccGGATGTtdw
GCM1_SPDEF_1 rTrsgGGCGGAtgyrywTCCGgs
GCM1_SPDEF_2 rTGvkGGCGGAygbsrsaTCCGgb
GCM1_SPDEF_2_3 rTgmkGGcGGAtg
GCM1_SPDEF_2_3_4 rTrmkGGCGGAtgykgsdTCCGssy
GCM1_SPDEF_2_3_4_5 rtgsGGGCGGAwgyrydTCCgkkt
HOXB2_SPDEF AmCCGGATgyrsgymATTA
TEAD4_SPDEF_1 rGaATGCGGAyrt
TEAD4_SPDEF_2 gGAATGCGGAtg
TEAD4_SPDEF_2_3 rGwATGCGGAwrTrbaTCCGkby
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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