DNA Binding Motif

						

			
Accessions: 6vvz_CDFM (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin
Length: 33
Consensus: TCTTGACTnnnnnnnnnnnnnTnTnTTAGACCA
Weblogo: 
PSSM: P0      A      C      G      T
01      5      5      6     80      T
02      0     96      0      0      C
03      0      0      0     96      T
04      0      0      0     96      T
05      0      0     96      0      G
06     96      0      0      0      A
07      0     96      0      0      C
08      5      6      5     80      T
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13     24     24     24     24      n
14     24     24     24     24      n
15     24     24     24     24      n
16     24     24     24     24      n
17     24     24     24     24      n
18     24     24     24     24      n
19     24     24     24     24      n
20     24     24     24     24      n
21     24     24     24     24      n
22      0      0      0     96      T
23     24     24     24     24      n
24     10     10     10     66      T
25     24     24     24     24      n
26      0      0      0     96      T
27      0      0      0     96      T
28     96      0      0      0      A
29      0      0     96      0      G
30     96      0      0      0      A
31      0     96      0      0      C
32     10     71      5     10      C
33     80      5      5      6      A
Type: Heterodimer
Binding TFs: 6vvz_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
6vvz_M (CarD-like/TRCF domain)
Binding Sites: 6vvz_O
6vvz_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.