Transcription Factor

						

			
Accessions: 6vvx_M (3D-footprint 20231221), 6vvy_M (3D-footprint 20231221), 6vvz_M (3D-footprint 20231221), 6vw0_M (3D-footprint 20231221)

			
Names: CARD_MYCTU, RNA polymerase-binding transcription factor CarD
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P9WJG3
Length: 159
Pfam Domains:     2-110 CarD-like/TRCF domain
Sequence: 
(in bold interface residues)		   1 IFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDV   60
  61 VGQEGLDKVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLS  120
 121 AGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAA
Interface Residues: 24, 26, 29, 67, 68, 71, 74, 75
3D-footprint Homologues: 6voy_C, 7jsa_J
Binding Motifs: 6vvx_CDFM TGCGTnTAAnAnAnnnnnnnnnnnnnAGTCAAGA
6vvy_CDFJM AACnCTGCCAGTCTAAnnnAnnnnnnnnnnnnnnGTCAAGA
6vvz_CDFM TCTTGACTnnnnnnnnnnnnnTnTnTTAGACCA
6vw0_CDFJM CTTGACtnnnnnnnnnnnnnTnTnTTAGACTGGCnngGT
Binding Sites: 6vw0_O
6vw0_P
6vvx_O
6vvx_P
6vvy_O
6vvy_P
6vvz_O
6vvz_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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