DNA Binding Motif

						

			
Accessions: HOXB2_PAX9_2 (HumanTF2 1.0), UN0563.1 (JASPAR 2024)

			
Names: HOXB2_PAX9, HOXB2::PAX9
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: sGTCACGChYCATTwv
Weblogo: 
PSSM: P0      A      C      G      T
01    204   1798    736    142      s
02      0      0   2533     23      G
03    111     68      6   2533      T
04      0   2533      0     73      C
05   2533     11      7      2      A
06      3   2533      9    164      C
07      0      0   2533      5      G
08      0   2533    590      7      C
09    652    925    236    720      h
10     15    941      0   2533      Y
11     21   2533    374      5      C
12   2533      0    446      0      A
13    112    347    275   2533      T
14      0     99      0   2533      T
15   1028      1    616    889      w
16   1029    827    679      0      v
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
PAX9_TF2 ('Paired box' domain, Homeodomain-like domain)
PAX9_TF1 ('Paired box' domain, Homeodomain-like domain)
P55771 ('Paired box' domain, Homeodomain-like domain)
P55771
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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