Transcription Factor
| Accessions: | PAX9_DBD (HumanTF 1.0), PAX9_TF2 (HumanTF2 1.0) |
| Names: | PAX9, PAX9_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P55771 |
| Notes: | Ensembl ID: ENSG00000198807; DNA-binding domain sequence; TF family: PAX; Clone source: Gene synthesis, Ensembl ID: ENSG00000198807; Construct type: TF2(3xFLAG); TF family: PAX; Clone source: Jolma et al. 2013 |
| Length: | 157 |
| Pfam Domains: | 5-128 'Paired box' domain 24-64 Homeodomain-like domain |
| Sequence: (in bold interface residues) | 1 MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARY 60 61 NETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSV 120 121 SSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYN |
| Interface Residues: | 17, 49, 50, 52, 54, 55, 71, 74, 77, 91, 93, 95, 101, 103, 119, 120, 121, 122, 124, 125, 128 |
| 3D-footprint Homologues: | 6pax_A, 1k78_A, 1pdn_C, 1gcc_A |
| Binding Motifs: | PAX9_DBD sGTCACGCwTSAsTGmm ELK1_PAX9 rCCGGAACyACGCwysAmTk HOXB2_PAX9_1 cccaTTaGTCACGCwTsRsTk HOXB2_PAX9_2 sGTCACGChYCATTwv |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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