DNA Binding Motif

						

			
Accessions: HOXB2_NHLH1_1 (HumanTF2 1.0)

			
Names: HOXB2_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 20
Consensus: stvaTTakgmmGCAGCTGCG
Weblogo: 
PSSM: P0      A      C      G      T
01     49     55     66     33      s
02     13     61     41    141      t
03     86    117     74      8      v
04    202     27     87     74      a
05     12      2      0    202      T
06     17      4     29    202      T
07    202      8     59     32      a
08     19     21    108     55      k
09     49      3    131     19      g
10     55     77     45     26      m
11     75     72     46      9      m
12     15      0    160     33      G
13      3    202     14      0      C
14    202      7      0      0      A
15      8      0    202     17      G
16      0    202      0     14      C
17     26      5     23    202      T
18      0      0    202      7      G
19      0    155     13     35      C
20      4     15    166     18      G
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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