DNA Binding Motif

						

			
Accessions: 1ic8_B (3D-footprint 20231221)

			
Names: HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
Length: 13
Consensus: TTaATAnntcGCC
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02      0      0      0     96      T
03     64     12     16      4      a
04     96      0      0      0      A
05      8      0      0     88      T
06     84      4      4      4      A
07     24     24     24     24      n
08     24     24     24     24      n
09      8     16      8     64      t
10     20     60      8      8      c
11     16      4     76      0      G
12      0     96      0      0      C
13      0     96      0      0      C
Binding TFs: 1ic8_B (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
Binding Sites: 1ic8_E
1ic8_F
			
Publications: Chi Y.I, Frantz J.D, Oh B.C, Hansen L, Dhe-Paganon S, Shoelson S.E. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Molecular cell 10:1129-37 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.